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06 - 09 - 2016

Treatment of a rare type of genetic obesity

Obesity linked to a POMC (a hormone that regulates appetite and weight) deficiency is a rare genetic disease currently without treatment. This disease leads to overeating and severe obesity before the patients even reaches his first year. However, two patients with the disease were treated with setmelanotide, a drug that is designed to replace the missing POMC. Today, these people have lost more than 1kg per week after 12 and 42 weeks of treatment. Their appetite decreased and their insulin level were effectively regulated. Their treatment is still ongoing. The effectiveness of setmelanotide had been studied and recorded in a model of obese macaque monkeys (Published in 2012). The drug could also be effective for other metabolic diseases.