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Scientific progress

13 - 03 - 2019

Ten years of research in mice

The British scientific information site Understanding Animal Research, founded in 2009, has published an article on some example of research using mouse models that have happened over the past 10 years.

Mice represent 72% of animals used in research in the United Kingdom, including transgenic animals (60% in France, excluding GM animals). This high proportion is explained by the relatively low maintenance cost of these small mammals and by the vast amount of scientific information available.

Ninety-eight percent of human genes have a similar gene in mice. These animals experience most human diseases and have organs and function (physiology) relatively the same as humans.

 

 



    2010: memory loss was corrected in an Alzheimer's mouse model;

    2011: gene therapy helped treat hereditary hemophilia in a mouse model ;

    2013: bone tissue obtained from human stem cells is transplanted into the mouse;

    2014: a kidney was regenerated in mice by stimulating cell multiplication;

    2018: almost 90% of the genetic abnormalities of amyotrophic lateral sclerosis are corrected by gene therapy in a mouse model;

               The first amendments to genetic abnormalities in the mouse embryo made possible using CRISPR-Cas9;

               Discovery in mice that glaucoma could be an autoimmune disease;

               Discovery in a mouse model that  polycystic ovarian syndrome (first cause of infertility) could be caused by a hormonal imbalance;

               two female mice give birth to pups.

    2019: many studies are ongoing. Follow the Understandinganimalresearch website or our Twitter account to be updated during the year.



Link:

http://www.understandinganimalresearch.org.uk/news/communications-media/ten-years-of-research-with-mice/