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Regulation

31 - 01 - 2018

A strategy to shape the 21st century’s toxicology

In the United States, the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has released its strategic plan for a new approach to assessing the safety of chemical and medical products.
 
ICCVAM specifies in a report dated from January 2018 the strategic approach to protect and improve public health through the evolution of the methods of toxicological evaluation, towards increased predictability and a reduction in the use of animals.
 
Three objectives have been identified:
• - Develop the upstream search for new methods, not just on a case-by-case basis and only when needed, by anticipating needs, unlocking budgets and developing the communication between researchers and the industry
• - Ensure a collaboration between the industry, researchers and federal agencies on how to develop efficient, flexible and robust methods that will ensure their use
• - Promote federal and international regulatory recognition of the new methods to become the norm.

 


These three objectives may seem complex, but they express realistically the scientific, technical, economic and regulatory problems encountered to change methods used for regulatory toxicology. The simple development of a method, even if it is effective, is not enough. It must be adopted by industries and recognized by all countries.
 
This strategic report with a realistic vision will favor the evolution of product safety assessment methods towards more predictivity and a reduction of the use of animals still unavoidable today.
 
The structure equivalent to ICCVAM in Europe is ECVAM.