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Animal research, Ethics, Institutions

09 - 09 - 2017

The scientific and ethical necessity of using animals in research

Marc Peschanski, director of I-Stem, recalls in an article of Le Point the ethical and scientific necessity of using animals in research.


Following the publication of a critical article on the use of animals in research in the weekly newspaper Le Point, Marc Peschanski, director of I-Stem and a leading researcher in the field of stem cells, stressed out essential elements put aside in this article.





Marc Peschanski recalls that the founding texts of bioethics, the Nuremberg Code and the Helsinki Convention, call for research to use animals to protect humans. A future drug must be tested on a species close enough to ours to evaluate effective doses, toxic doses and its active-lifespan in the body.


He adds that cells or tissues from living organisms, in the lab, do not behave as they do in these same organisms. This limits the interest of in vitro models.


The quality of animal models is extremely important for studying a disease and the effects of treatments. In all cases the research uses the animal models that are closest to the treated condition.


Some models that reproduce painful diseases can cause pain. It is quite rare and always reduced as much as possible. Marc Peschanski recalled that the regulation imposes the 3Rs rule: "replace as soon as possible, reduce the number of animals to the minimum necessary and refine to minimize animal suffering as much as possible. National and International Project Assessment Commissions are very careful about this point. "