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14 - 03 - 2017

A protein to improve cancer immunotherapy

Our immunity has killer cells that can supress cancerous cells and those are the cells that immunotherapy tries to stimulate. But regulating cells (Treg cells) sometime reduce the effectiveness of killer cells to the point of protecting the tumour.

Now, it has just been discovered that a protein called moesin stimulates the production of Tregs. Thus, a study looking at the effect of immunotherapy against melanoma showed that transgenic mice lacking moesin mostly survived, unlike those that still had moesin.

All that needs to be found is substances capable of inhibiting the activity of the moesin in order to envisage their use in immunotherapy treatments against cancer.