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04 - 06 - 2018

Personalized medicine and animal research

The National Academies of Sciences, USA, has just published a report on modelling of animal research diseases in the field of precision medicine.

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Precision medicine or personalized medicine aims to identify at the patient level the factors involved in the development of his disease.

 

Animal research will be an essential element for the advancement of precision medicine if it meets the following conditions. It will have to:

             - identify and reproduce the expression of the genome

             - relate them to external and behavioural factors

             - specify the clinical interest of each of these factors

             - use computer tools to link animal and clinical data

 

 

 

The symposium held on October 5 and 6, 2017 and whose proceedings have just been published, drew on these principles to clarify how future animal models will be:

             - created from patient data

             - studied in order to discover the mechanisms that lead to the disease in each patient specifically.

In addition, the concepts of study reproducibility, animal welfare and regulatory frameworks were explored.

 

All aspects of non-clinical research were discussed: model organisms, public opinion, bioethics, rare diseases, big data, translational research and extrapolation, in vitro models and alternatives, induced stem cells, organoids, safety and risk assessments.

 

Catherine Nguyen, Director of the ITMO Genetics, Genomics and Bioinformatics presented the France’s plan in the field of genomic medicine and mentionned the publication of the French 2025 Genomic Medicine report delivered to the Prime Minister by Aviesan in January 2016 and which aims to apply genome sequencing to clinical practice.

 

The conclusion of the symposium highlighted the need for collaborations between different fields of biomedical research to advance personalized medicine, which remains an exciting but very demanding goal.

 

https://www.nap.edu/catalog/25002/advancing-disease-modeling-in-animal-based-research-in-support-of-precision-medicine

https://www.aviesan.fr/aviesan/accueil/toute-l-actualite/plan-france-medecine-genomique-2025