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25 - 06 - 2018

A patch to treat mouth inflammation

A patch aimed at treating inflammation of the mouth has successfully passed preclinical and clinical phase I trials.
Lichen planus and recurrent stomatitis are inflammatory conditions of the mouth that cause sustained and repeated pain and erosions of the oral mucosa.
Current treatments consist of mouthwashes or creams containing anti-inflammatories. Unfortunately these forms of treatment do not allow for a durable and concentrated contact of the drug with the injured area, which greatly reduces the effectiveness.
Research teams are developing a new mucoadhesive patch that seems to address this problem.
This patch is built on an electrospun polymer * whose physical characteristics and cytotoxicity were first evaluated by physical, biochemical and cell culture methods. Then a tolerance test of this electrospun polymer was carried out in a clinical trial.
The polymer was then turned into a drug by incorporating an anti-inflammatory: Clobetasol propionate 17 (CBT).
The release rate of CBT from the patch was developed in vitro on tissues and the oral mucosa of pigs. Then the researchers checked in vivo, in pig animal models **, for:
- good adhesion to the mucosa
- the release kinetics of CBT (concentration and duration)
- the absence of mucosal lesions.
Following these good results, a phase II clinical trial in patients is on its way.
* weaving guided by electrostatic forces that produce a multilayer tissue with specific pores that can be loaded with different substances
** test on tongue, cheeks and gums