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Animal research

27 - 01 - 2017

Organ transplants: the complex pathway of chimeric animals

To address the inadequate supply of organs for transplants, researchers are attempting to produce human organs in animals. Today, the pig that has a rapid reproductive cycle with a rapid growth and a similar corpulence to humans seems the most interesting animal species, which does not prevent more functional studies in rodents.

The discovery of the CRISPR genetic engineering tool makes it possible to quickly create precise and complex biological models. This is why publications on the production of human organs by chimeric animals are currently numerous. An article in Nature summarizes the most recent results and presents both the technical barriers that persist and the ethical issues raised by these models.