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12 - 08 - 2016

No fewer than 930 genes involved in alcoholism in rats

The large amount of genes associated with alcoholism is no good news for future drug treatments. These genes are closely related. The study conducted in animals by the university of Indiana hasn’t identified any major gene or any directly linked to a specific disorder. Moreover, the majority of the genes are expressed in regulatory regions. This explains why one of the best predictors of alcoholism in humans remains consumer behaviour within a family. How about genetic inheritance or environmental influence? The environment can trigger the expression of genetic trends leading to alcoholism. There is however a glimpse of a hope: the signalling pathway of the glutamate receptor (which controls the reward system in the brain) could be a therapeutic target because of the number of ‘alcoholic’ genes associated with it.