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03 - 11 - 2017

Kidneys: progress for dialysis?

A new type of biological and immunocompatible arteriovenous graft was successfully tested in baboons.

 

Hemodialysis generally requires the creation of a connection (fistula) between a vein and an artery in the arm to have sufficient blood flow.

 

This fistula is sometimes replaced by the graft of a vein taken from the patient. To avoid taking a vein, artificial veins are available but are more likely to clot or become infected.

 

 

Researchers are trying to develop a better type of arteriovenous graft.

 

They created, with human skin stem cells deposited on a protein matrix of cattle, tubes 6 mm in diameter and 15 cm long, which they then totally decellularized.

 

These tubes grafted on a baboon model of hemodialysis were colonized by the cells of the recipient animals to reconstitute blood vessels. Permeability at 6 months was maintained in three out of five animals, which is a very good result.

 

There is evidence that this type of acellular and immunocompatible graft may become an additional surgical option for hemodialysis. Clinical trials are envisaged.