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28 - 09 - 2016

Influenza : the war against the live virus

Knowledge of immune responses to viral contamination comes from in vitro studies and observations of humans and infected animals. There is no way of visualizing the battle that the actors of the immune system, cells, are leading in situ against viral infections.

Now researchers have developed a real-time imaging technique to visualize this fight. They applied it to an in vivo model of influenza infection on the trachea of a mouse. They found that the dynamics of action over several days, corresponded to what is known about the reaction of immune cells at a molecular and cellular level. This new method gives a complete and realistic vision of the immune response and will be used to increase the understanding of viral infections and consequently find new treatments.