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Health, Scientific progress

12 - 05 - 2016

IBD treated in mice

French researchers have shown in mice that a genetic modification can result in the impairment of the gastrointestinal bacterial floral and the occurrence of IBD (inflammatory bowel disease). The alteration of the flora then induces IBD in mice without genetic modifications. The common point between the genetic and bacterial mechanisms of action resides in the decrease of the synthesis of indole derivatives. The administration of products mimicking the indole derivatives has treated mice. The same genetic and bacterial mechanisms exist in humans. The treatment remains to be tested on humans.