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04 - 04 - 2017

Fixing Shoulders

The rotator cuff is the structure made of tendons that gives the shoulder the strength to lift an arm. Its rupture leads to disabling pain. Restorative surgery can be quickly followed by a second rupture because of the limited regenerative capacities of tendons.

In vitro repair of tendons by mesenchymal stem cells (MSC) has yielded good results. In vivo studies are more difficult. A study on a rat model for the rupture of the cuff has demonstrated an improvement in healing thanks to a biomimetic matrix containing MSCs. Following these good results, this matrix will be studied on a larger animal model, the rabbit then the sheep. This therapy could be applied in the future to tendon ruptures.