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23 - 05 - 2018

Female Infertility: The Origin of Polycystic Ovary Syndrome Discovered in Mice

A study in patients and mouse models helped discover the neuroendocrine origin of polycystic ovary syndrome and a potential treatment.
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Polycystic ovary syndrome (PCOS) affects 10% of women of childbearing age. It causes an overproduction of male hormones, ovarian dysfunction and infertility.
 
A team of Inserm researchers - University of Lille - CHU Lille - Center Jean-Pierre Aubert, published the results of a study that increases the knowledge of this syndrome.
 
Based on the observation that antimulterian hormone (AMH) is secreted in greater quantity in patients and that this hormone can have an effect on female fetuses, the researchers measured its levels during pregnancy and found that it was higher in women with PCOS.

 

 

 


To learn more about the effect of this elevation on the offspring, researchers reproduced it in a mouse model.
 
They found in mice treated with AMH during pregnancy:
     - an excess of testosterone linked to a neuroendocrine stimulation and a reduction in the transformation of testosterone into oestradiol by the placenta
     - the masculinization of female fetuses
     - neuroendocrine (hypersecretion of GnRH, LH and androgens) and reproductive (PCOS) changes in females once adults.
 
Finally, the researchers administered to these female mice mimicking PCOS a treatment regulating the production of GnRH and LH which restored their fertility.
 
This work has revealed PCOS-related neuroendocrine abnormalities and a therapeutic pathway to treat it.

 

https://presse.inserm.fr/vers-une-comprehension-de-lorigine-du-plus-frequent-des-troubles-de-linfertilite-feminine/31387/

https://www.nature.com/articles/s41591-018-0035-5