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Fundamental research

23 - 01 - 2018

Cutaneous healing: an immune response of remarkable effectiveness

A particular immune reaction has just discovered on a mouse model for skin lesions. It involves the microbiota, avoids infection and accelerates healing.

 

The microbiota is subject to numerous studies that show the deep interactions it has with organisms.

 

Researchers took interest in the interactions between bacteria on our skin and healing.

 

For this they used a mouse model.

 

First, they observed that in the presence of the bacteria usually present on the skin, Staphylococcus epidermidis, the immune cells of the mouse produced unusual T-cell immune cells that express immune healing and defence genes, rather than inflammation.

 

Then, the researchers performed a skin biopsy on mice whose skin was colonized with Staphylococcus epidermidis and in mice on which this bacterium was absent. Five days later, healing was more advanced and inflammation was reduced in the presence of the bacteria.

 

 

Researchers now plan to extend this research to other animals and humans to validate these findings and to understand the mechanisms at play.

 

After which the reproduction of the microbiota’s effect that accelerates healing could be applied to diabetics who heal very badly, or prevent dangerous infections.