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24 - 04 - 2018

Curing diabetic wounds

The excess in the production ofprotein TSP2, stimulated by glycemia, could explain the origin of diabetic wounds.

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One of the toughest complications of type 2 diabetes is the emergence of woundson one’s feet and legs that don’t heal. They can linger for months, resulting in pain and risks of infection.

 

During the annual congress for experimental biology, a research team has presented their results for studies on this subject.

 

They targeted cells in the wounded area, but also its extracellular matrix. This matrix is not only the structure supporting the cells, but also a source of nutritive and regulatory substances of the immune response, and in the creation of blood vessels.

 

Protein TSP2 belongs to this matrix. We know that people suffering from diabetes have a higher level of TSP2than non-diabetic people.

 

In vitro and mice modelstudies helped the team discover that:

  • Diabetic mice heal better and faster in the absence of TSP2.
  • Higher levels of sugar will increase the production of said protein.

 

 

The healing process improves amongst mice lacking the TSP2 protein (A: diabetic mouse, B: mouse without TSP2)

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hese studies confirmed the existence of alink between diabetic hyperglycemia and the interference of the healing process.

 

Researchers are now trying to perfect a biomaterial derivative of the extracellular matrix without the presence of TSP2. It will be tested on mice models before being locally administered. Another study would be the improvement of a treatment that would inhibit the production of TSP2.

 

https://www.eurekalert.org/pub_releases/2018-04/eb2-nhf041218.php

https://experimentalbiology.org/2018/Home.aspx