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Animal research

03 - 03 - 2017

Controlling cancerous stem cells

Cancerous ‘stem’ cells (CSCs) have the ability to recreate a tumour after treatment, even if there are very few. For a tumour to be permanently treated, CSCs must be removed or neutralised. French researchers have discovered that a microRNA* has to potential to stop the proliferation off CSCs in breast cancer. After screening among the known micro RNAs, they discovered that the microRNA miR-600, directly influenced the activity of CSCs: overexpression of this microRNA leads to an inhibition of the CSCs in vitro and in a mouse model with tumours. Inversely, low levels of miR-600 is associated to poor prognosis in 120 patients. This discovery paves the way for new therapeutic strategies. 

 

* MicroRNAs regulate cell activity