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12 - 09 - 2016

Chestnuts, allies against an aggressive cancer ?

Glioblastomas are brain cancers that leave little hope to patients: less than 3% survive more than 5 years. This is one of the deadliest cancers. The treatments (chemotherapy, radiation) are ineffective mostly because of the persistence of the cancerous stem cell (CSC) that regenerate the tumour. French researchers have therefore tested in vitro on patient stem cells the anti-CSC potential of hundreds of active ingredients. Escin, a horse chestnut extract known for its anti-cancer properties, reduced the survival of CSCs without affecting healthy cells. This substance makes CSCs more sensitive to chemotherapy. The next step is to verify the effectiveness of escine or derivatives in in vivo models of glioblastomas.