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06 - 02 - 2017

Bacteriophages against cholera

Vibrio cholerae is responsible for about 100 000 deaths/ year and numerous epidemics. Vaccination and the improvement of sanitary conditions of populations remain the best protections against this bacterium. Antibiotics are also prescribed but they promote the development of resistant strains.

Tufts University’s approach that consists of infecting the pathogen with viruses that destroy it, is therefore interesting. Tests on animal models show that a cocktail of three viruses reduces the number of vibrio in the small intestines and avoids diarrhoea and weight loss. These bacteriophages could be a new tool in the treatment of this disease.