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Animal research

04 - 12 - 2017

Animal models

Françoise Barré-Sinoussi and Xavier Montagutelli from the Pasteur Institute explain animal models.


In a July 2015 publication, which GIRCOR translated into French, two researchers from the Pasteur Institute, Françoise Barré-Sinoussi, winner of the 2008 Nobel Prize in Medicine, and Xavier Montagutelli, recall the reasons for the use of animals in scientific and medical research.



The similarities between mammals and humans are very important. They share many diseases such as diabetes, hypertension, cancer, allergies and many infectious or parasitic diseases, to the point that 90% of veterinary drugs are very similar or identical to human drugs.


The extreme complexity of living organisms such as humans and mammals does not allow today to simulate their function using in vitro artificial systems.


The results obtained on animal models are not always transposable to humans. The 95% homology between human and mouse genes gives way to many differences that are more and more understood and taken into account in research projects and the interpretation of results. These question even less the interest of animal models as they can be the source of discoveries and new therapies.


Different inbred lines of mice can give different results. Again, the point is not that animal models are unreliable, but that they reproduce and allow to explore the variety of symptoms observed in humans who also react differently to the same diseases.


Xavier Montagutelli presents this publication and the regulatory framework for animal research in a video.